The mission of the UCSF Alpha Stem Cell Clinic, part of the CIRM Alpha Stem Cell Clinic Network, is to accelerate the tempo of (1) pre-award planning with sponsors, (2) clinical trial activation, (3) patient accrual and trial completion, to (4) expand access to these therapies by underserved populations with disorders studied by the ASCC network, and to (5) establish a disease-team approach that promotes participation in the CIRM-alpha Network trials.

Program Overview

The UCSF Alpha Stem Cell Clinic is a new program dedicated to research that rapidly develops stem cell-based therapies that can cure hereditary blood and immune system disorders, highlighted by ongoing gene therapy trials in hemoglobin disorders and primary immunodeficiencies in children and adults.  In addition,UCSF researchers conduct studies of  anti-inflammatory and immune-modulatory cellular therapies, highlighted by mesenchymal stem cell trials in patients with lung injury after trauma and serious infection and the use of T-regulatory cells in disorders such as diabetes and after solid organ transplantation. 

California Institute of Regenerative Medicine Alpha Clinics Logo
Funded through a four-year, $8 million grant from the California Institute for Regenerative Medicine, the UCSF Alpha Stem Cell Clinic is part of a statewide effort to develop a network of “Alpha Stem Cell Clinics” that can accelerate the development of  therapeutic agents that are derived from stem cells. This includes:

Identifying the most promising cellular therapies and accelerating their path toward human trials.

Building and implementing an infrastructure to support launching and running multiple stem cell clinical trials.

Coordinating patient care with protocol implementation in a way that ensures treatment safety and effectiveness during and after the studies.

The UCSF Alpha Stem Cell Clinic also collaborates with other Alpha Stem Cell Clinics and research partners to expedite stem cell studies by streamlining processes, integrating resources and sharing data.